ABSTRACT
In 1950 Gofman and his co-workers demonstrated the possibility of separating plasma lipoproteins into classes based on their hydrated density. Their work led to a huge refinement in risk classification over the previous one of simply measuring total serum or plasma cholesterol. In 1950 Gofman, J. W., Lindgren and his co-workers demonstrated the possibility of separating plasma lipoproteins into classes based on their hydrated density. Their work led to a huge refinement in risk classification over the previous one of simply measuring total serum or plasma cholesterol. Toshima, H., showed that the traditional Japanese diet had changed; currently Japanese ingest 25% of calories from fat, 60% from carbohydrate and 15% from protein. Despite these changes there has been reduced incidence of stroke and no increase in coronary heart disease. Another study found that between 1950 and 1985 cardiovascular mortality in Japanese men and women aged 30 to 69 had decreased by over 38%.
