ABSTRACT
This chapter focuses on the most common configuration for the continuous flow electrophoresis (CFE) device, typically referred to as the Hannig device. The CFE apparatus consists of a rectangular flow chamber with dimensions such that the length of the chamber is much greater than both the width and the thickness of the chamber. The method of lines is applicable to the solution of initial-boundary-value problems, which involve a time-like coordinate and one or more spatial coordinates. The success of this approach on two other transport problems led to its application to continuous-flow zone electrophoresis. The chapter turns to the integration of the ordinary differential equations generated following spatial discretization. It is generally recognized that accurate and stable integration in a time-like coordinate can be done quite efficiently with an implicit, variable-order, multistep method. The chapter demonstrates the application of numerical methods for the quantitative description of mass transfer behavior in the CFE device.
