ABSTRACT
This chapter examines the effect of prolonged stimulations of various subcortical structures prior to amygdala kindling in cats. Cortical electrical stimulation of the epileptic focus at a high frequency had effects on the focal cortical seizure status. In the present study, electrical stimulations of different targets were applied to rats in which focal seizures were induced by focal application of kainic acid (KA). In the present study, a KA-induced limbic seizure status model was used to examine the effectiveness of electrical stimulation. The results demonstrated that additional electrical stimulation epileptic focus induced by a KA injection facilitated the epileptic activities of the focus. The effect of continuous electrical stimulations of the epileptic focus of the subthalamic nucleus were examined using a kainic acidinduced focal seizure status model. Bilateral high frequency stimulation of both subthalamic nuclei (STNs) or of the STN ipsilateral to the epileptic focus reduced the number of seizures in rats with focal cortical seizures induced by kainic acid.
