ABSTRACT
There are few statements to rival “Doctor, I feel tired all the time” in their ability to frustrate the neurologist. Fatigue is vague, imprecise, and difficult to measure. In theory it can be a symptom of most of the contents of the Oxford Textbooks of Medicine and Psychiatry, but in practice it is often unexplained. It is also common, and can be incapacitating. Most neurologists will admit to having little idea of how to manage patients once the usual tests have proven negative, as they so often do. This chapter will begin by describing the nature of chronic fatigue, and will then turn to the management of the chronically fatigued patient in neurological practice.
