ABSTRACT
Atherosclerotic cardiovascular disease is the leading cause of morbidity and mortality in the Western world. Despite the established benefit of therapeutic interventions aimed at traditional cardiovascular risk factors, the majority of clinical events are not prevented. It remains uncertain what influence many of these interventions exert on atheroma to result in reduced clinical event rates. By identifying the impact that interventions exert on atherosclerotic plaque, a number of novel therapeutic strategies have the potential to fulfil a major role in the development of effective atheroprotective strategies.
