ABSTRACT
To address the question of gonadotropin stimulation in humans, prospective or retrospective studies are required with experimental groups who have only undergone ovulation induction, as opposed to the more involved protocols of assisted reproduction. One such study has been reported, in which a large case-control prospective study was undertaken to compare obstetric outcomes of singleton pregnancies in women who had undergone ovulation induction to comparable unstimulated control females75. This study described an increased relative risk of gestational diabetes mellitus and pregnancyinduced hypertension. Neither of these illnesses can be attributed specifically to the hormonal stimulation, as the cause may be related to the underlying fertility or treatments75. Imprinted genes have yet to be examined.
