ABSTRACT
Although the world’s first IVF baby Louise Brown was conceived within a natural menstrual cycle1, it soon became obvious that if IVF was to progress from a research tool to a clinical treatment, the use of controlled ovarian hyperstimulation was necessary. Initially it was the use of clomiphene citrate2 that was utilized to produce multiple follicles, soon to be followed by injections of gonadotropins3. Soon the use of the natural cycle was virtually abandoned and various regimens utilizing follicle-stimulating hormone (FSH) were introduced.
