ABSTRACT
Because of the sensitivity of oocytes to antiseptics, the vagina is not sterilized prior to oocyte collection. Consequently, a sterile needle is inserted through the vagina, potentially pushing organisms from the vaginal flora intraperitoneally. Initially it was thought advisable to cleanse the vagina with saline or sterile water, but subsequent advice was that this just activated the vaginal organisms. Most clinicians use no preparation of the vagina, and fortunately we have learnt with time that the infection rate is low, although it does occur in 1 in 300 oocyte collections. Although usually not serious, and responsive to a course of antibiotics, the infection can sometimes be more severe and pelvic abscess may result, requiring drainage.
