ABSTRACT
The anti-inflammatory effect of transdermal delivery of a diclofenac sodium patch was evaluated. The patch matrix consists of ethyl cellulose N-20 and polyvinyl pyrrolidone K-30 to control the drug release. In this study, the patches were prepared with ethyl cellulose N-20 (EC-N20) and polyvinylpyr-rolidone K-30 (PVP K-30) at weight ratio of 6:4 and 7:3 for EC/PVP-6/4 and EC/PVP-7/3 patches, respectively. The anti-inflammatory effect was determined by evaluating the swelling of rat’s paw oedema that was induced with 1% carrageenan suspension. The results showed that the high concentration of PVP K-30 resulted in less rigid patch with pore structures. In addition, it improved the anti-inflammatory effect of diclofenac sodium resulted in higher efficacy of EC/PVP-6/4 than that of EC/PVP-7/3. There were no significant differences on drug stability observed for both formulations. It can be concluded that controlling diclofenac sodium released from patch using PVP K-30 could give benefits for anti-inflammation therapy.
