ABSTRACT
The study was designed to investigate the therapeutic effect of Continuous Infusion (CI) and Intermittent Bolus (IB) administration of furosemide on patients with NYHA class III-IV heart failure hospitalized in Dr. Soetomo Hospital Surabaya. Thirteen patients received CI of furosemide and 10 patients received IB furosemide. Total urine output, net urine output (nUO/24 h) and urinary sodium excretion were monitored over 24 h. nUO/24 h of IB and CI were 1292 ± 299 mL and 2081 ± 637 mL, respectively. CI group showed significantly higher total urinary output than IB group (3399 ± 793 mL/ 24 h vs. 2556 ± 343 mL/24 h). The urinary sodium excretion of CI and IB were 302 ± 73 mmol/24 h and 228 ± 58 mmol/24 h, respectively. CI of furosemide resulted in higher total urinary output, net urinary output and urinary sodium excretion than IB furosemide in patients with NYHA class III and IV heart failure.
