Drug-induced lung disease and radiation-induced disease

As medical therapeutics become increasingly complex, druginduced respiratory disease (DIRD) has become more common. A wide range of chemotherapeutics, biologics, antiarrhythmics, drugs of abuse, and antibiotics, among others, are known causes of diverse lung disease. Hundreds of agents have been described in relation to a known DIRD. Radiographic patterns varywidely and can be acute, subacute, or chronic. Making a confident clinical diagnosis is difficult. This chapter seeks to aid the clinician in understanding the scope, risk factors, evaluation, radiology, and treatment of this complex group of syndromes.1