chapter  12
14 Pages

Antigen receptor diversification during immune responses

WithMiri Michaeli, Ramit Mehr

The fact that most immunoglobulin variable region (IgV) genes sampled are heavily mutated poses, on one hand, a challenge that must be overcome when processing IgV gene sequencing data. On the other hand, many analysis methods based on identifying these mutations can yield very useful insights regarding B cell clonal dynamics and antigen-driven selection. This chapter reviews the problems and solutions posed by SHM, the SHM-based analysis methods, and some insights gleaned from these analyses.