chapter  13
14 Pages

Quantitative modeling of mast cell signaling

WithLily A. Chylek, David A. Holowka, Barbara A. Baird, William S. Hlavacek

FcεRI is a multi-subunit receptor found on the surface of mast cells and basophils. Stimulation of this receptor can lead to release of histamine and other mediators that are involved in the allergic immune response. Thus, understanding the workings of FcεRI signaling brings us closer to understanding one of the most widespread health conditions in the developed world. FcεRI-mediated signaling processes are inherently complex, involving highly interconnected systems in which quantitative factors can play a decisive role. Such systems can be difficult to reason about using intuition alone, but computational models can extend our reasoning abilities and enable us to develop nontrivial and experimentally testable hypotheses.