chapter  17
20 Pages

Viral fitness landscapes

A physical sciences perspective
WithGregory R. Hart, Andrew L. Ferguson

Immunological synapses are examples of complex phenomena within immunology that emerge from the communication of immune system cells with each other or with microbes. These structures are employed at multiple stages in adaptive and innate immunity and they fit into the wider execution of larger programs such as the response to a pathogen, or the active maintenance of immunological tolerance. This chapter outlines the author’s personal experience of theoretical and experimental approaches to the immunological synapse and a wish list for the future that envisions extensive use of theory and data driven modeling to increase our ability to treat infection, cancer, and inflammatory diseases.