chapter  5
20 Pages

An introduction to rule-based modeling of immune receptor signaling

WithJohn A.P. Sekar, James R. Faeder

In this chapter, we will explore the origins of complexity in macromolecular interactions, show how rule-based modeling can be used to address complexity, and demonstrate the construction of a model in the BioNetGen framework. We highly recommend that users start with RuleBender, which is a graphical user interface for BioNetGen that has text highlighting and syntax checking as well as interactive visualization and simulation capabilities.