chapter  6
12 Pages

Boolean models in immunology

WithReinhard Laubenbacher, Elena Dimitrova

The use of mathematical models in immunology goes back to the 1970s, mostly focused on capturing the dynamics of different cell populations in a host, generally with the aid of ordinary differential equations. Since then, modeling has become an important technology in this field. Systems of ordinary differential equations still represent a key modeling framework, but they have been joined by models of other types, in particular Boolean models and their generalizations, as well as agent-based models. Modeling with differential equations as well as agent-based modeling is discussed elsewhere in this volume. In this chapter, we focus on the use of Boolean models and their generalizations in immunology.