chapter  8
19 Pages

Gastric Cytoprotection and Adaptation to Ethanol

ByStanislaw J. Konturek, Jerzy Stachura, Jan W. Konturek

The gastrointestinal tract, particularly the stomach, is constantly exposed to various irritants and aggressive factors of endogenous origin such as gastric acid, pepsins, lipases, and bile as well as ingested elements including ethanol, certain drugs, and bacteria. Stomach exposed to repeated insults of hostile environment has the ability tor quick adaptation to survive the challenge of everyday life and to withstand the action of various irritants. The protection of gastric mucosa obtained by the administration of exogenous PG is called "direct cytoprotection." The importance of vascular factor in cytoprotection is supported by the fact that PG failed to protect the in vitro gastric mucosa against various types of damage. The adaptive cytoprotection induced by hypertonic saline was shown to be accompanied by a marked increase in the mucosal blood flow. Cytoprotection induced by ethanol is a complex phenomenon in which cellular and tissue mechanisms amplify, leading to the very effective and impressive phenomenon.