Severe and acute adverse cutaneous drug reactions II: DRESS syndrome and serum sickness-like reaction

DRUG RASH WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS (DRESS) Background Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome, formerly termed “drug hypersensitivity syndrome” (HSS), is a severe potentially fatal adverse drug reaction characterized by skin rash, fever, lymph node enlargement, and single or multiple organ involvement, characteristically occurring in a delayed fashion between 3 and 8 weeks after starting treatment with the culpable drug for the rst time.