ABSTRACT
Many systemic infections have cutaneous presentations that sometimes are nonspecic. These cutaneous signs and symptoms may be helpful in making the proper diagnosis, prescribing the appropriate therapy, and assisting in prevention. Some clinical manifestations of systemic infections highlight the possible infectious etiology for unusual cutaneous lesions. Bacterial systemic infections may be more common in remote areas of the world; these same bacterial diseases also may be seen, however, in travelers or immigrants from these areas. Some of these infections, such as plague and melioidosis, are potential biologic weapons used for bioterrorism.
