ABSTRACT
This chapter analyzes how enzyme biocomputing paradigms have been developed, how their complexity has grown from single logic operations to networks, the evolution from model to applied systems, and their interface with different materials to achieve applied systems and devices. Binary logic operations are the basis of digitalization and computing. In electronics, digital circuits are built on combination of logic gates. There are different operators that differ in the nature of the transformation they perform; each operator tethers a relationship between each combination of input signals and the specific output given. More common logic operators are AND, OR, XOR, NAND, NOR, NOT, InhA, and InhB. The output signals of the enzyme logic gates mean a change in the environment that can be coupled with materials specifically designed to sense and act accordingly. Functionalizing electroactive surfaces with signal-responsive polymers yielded the establishment of a completely new electrode switching behaviour.
