ABSTRACT

Stem cells have greatly revolutionized the clinical arena. Cell-based therapy is a remarkable advancement in the medical and scientific community. In modern medical therapy, stem cells are used in various ways to develop regenerative medicine, drug screening, and other biomedical therapies. Unspecialized stem cells can produce matured cells of different forms, such as blood cells, nerve cells, and cardiac muscle. Normally, stem cells are self-renewing. The need of stem cells has increased dramatically for various clinical purposes, which cannot be served by traditional approaches. Therefore, bioreactors are being used to generate significant quantities of cells. This chapter discusses the various bioprocessing strategies related to stem cells, especially design and operating parameters of bioreactors for stem cell cultivation. Furthermore, various bioreactor types for robustly producing different cell lineages are discussed. Thus, this chapter provides academicians and researchers with a glimpse of the latest technological perspectives on the mass production of different stem cell types under controlled conditions.