ABSTRACT
Since the 1960s, pharmaceutical companies have been charged
with monitoring the characteristics of their oral dosage forms
dissolving in controlled media. Early dissolution testing focused on
the quality control of the dosage form manufacturing. Dissolution
testing provided unique capabilities in monitoring integrated
production parameters that affect the dissolution rate: tablet
hardness, excipient control, particle size, etc. The technique became
required for the routine testing of oral dosage forms worldwide.
The early history of dissolution testing is well documented in the
literature.1−3
