Hepatic radioembolization with yttrium-90 (90Y) microspheres is unique in many ways compared with other methods of treating hepatic malignancy, including the use of radiation, size of the infused microsphere, the number of particles administered, and variable technical considerations involved in the infusion. While radioembolization imparts some of the same procedural
risks to surgical interventional and other forms of liver-directed therapy (i.e., fulminant hepatic failure), it can result in a variable constellation of both normal treatment eects and possible complications. us, image interpretation following 90Y can be confusing, particularly when performed in a vacuum of clinical information and without a robust understanding of radioembolization. is chapter provides a detailed discussion of the imaging and correlative clinical ndings following 90Y therapy with an emphasis on clinical relevance and underlying mechanisms.