Traumatic brain injury (TBI) has the potential to visit tremendous change upon an individual and, in some cases, devastation to life as it might have been known to the person prior to injury. Discharge planners frequently must focus on the immediate discharge environment following a treatment setting. Individuals will likely require one or more of the depicted treatment settings, in particular, benefitting from involvement in multiple settings for rehabilitation. This chapter offers a broadened view of discharge planning that extends years beyond injury, and provides insights into the nature of the long-term problems encountered with methods of addressing those problems. The sequelae of TBI can be many and varied with relatively little congruency between any two injured persons. The literature is fairly clear about the cumulative nature of injury to the brain seen with repetitive trauma. The statistics regarding survival of family systems following return of a person with TBI to the home are disturbing.