The skilled therapist of the brain-injured person requires an understanding of the underlying anatomy and physiology, its relationship to the injury, the mechanisms of learning, and the creative array of multimodal therapeutic skills that he or she has at his or her disposal. Therapies are designed by the therapist to elicit a key response from the client, and this leads to one part of a successful rehabilitative program. Neuroplasticity refers to the ability of the brain to change its structure and organization as the organism encounters its environment. Learning and memory are closely associated and sometimes difficult to separate except for academic purposes. The rehabilitation process involves the returning to wholeness of the entire person and, as such, makes demands on many systems, from the locomotor to the cognitive. Rehabilitation, as a process, requires the work of several respective professions. Multimodal rehabilitation refers to a therapeutic approach that attempts to address the individual as a whole person.