ABSTRACT
Nanodiamond (ND) particles are versatile platforms for nanomedicine therapy and imaging in that they can be scalably produced to carry a broad spectrum of payloads with improved efficacy and safety. This versatility is rooted in the fact that NDs possess a number of key properties that are integrated into a single carrier. Root canal treatment is a standard therapy for removal of infected vascular and nerve tissue, decontamination, and obturation of debrided root canals with an inert filling material called gutta percha. Amoxicillin is a broad spectrum bactericidal agent against organisms such as Staphylococcus aureus, commonly involved in endodontic reinfections. Resistance to chemotherapy continues to be a significant obstacle for cancer treatment and contributes to treatment failure in more than 90" of metastatic cancers. Drug combination development is a challenging task, given the virtually infinite parameter space that exists when integrating multiple drugs to form a maximally efficacious and safety drug–dose ratio.
