Prediction of Chemotherapy Outcome in Patients
This chapter shows the ability of the physical oncology approach to not only understand and describe drug delivery, but also predict chemotherapeutic outcomes based on physical parameters from individual patients. It demonstrates that the key parameters in accurately predicting the amount of cancer cells that will be killed in chemotherapy treatment are the blood volume fraction (BVF) and the radius of the main blood vessels (rb) involved in delivering blood and nutrients to the tumor. This lays the groundwork for further human clinical studies, specifically in colorectal cancer (CRC) metastatic to the liver, as well as further research into the contributions of other factors in the microenvironment to drug resistance. The chapter performs an analysis on the histopathology from posttreatment specimens similar to that described for the glioblastoma multiforme (GBM). It also demonstrates the mathematical model's ability to account for the tumor's microenvironmental effects on the efficacy of drug delivery.