chapter  48
The central role of Aβ amyloid and tau in the pathogenesis of Alzheimer’s disease
ByCraig W. Ritchie, Colin L. Masters
Pages 16

In autosomal dominantly inherited AD, processing of APP creates a high ratio of Aβ42 (‘long’ Aβ of 42 amino acids) to Aβ40 (‘short’ Aβ of 40 amino acids). ese processes are discussed later in this chapter. e more insoluble long Aβ is the primary constituent of the amyloid plaque. However, immunocytochemical techniques have demonstrated that diuse plaques contain not only Aβ42 but also Aβ40 and, in a small proportion of plaques (most of which have a dense amyloid core), Aβ(16-40/42) (the p3 fragment) (Dickson, 1997). Perivascular amyloid identied in the congophilic angiopathies predominantly consists of Aβ40 (Suzuki et al., 1994; Barelli et al., 1997).