ABSTRACT

As advances are made in our understanding of the mechanistic underpinnings of membranoproliferative glomerulonephritis (MGPN), the classication and nomenclature of MPGN as a clinicopathologic entity is being revisited. Children with MPGN may present with nephritic syndrome, nephrotic syndrome, asymptomatic proteinuria, or a nephritic-nephrotic clinical picture. Despite an increased understanding of its pathogenesis, optimal treatment of MPGN remains uncertain.