ABSTRACT
Congenital obstructive uropathy is characterized by compromised urine ow or transport that begins in utero and can impair fetal renal development and function. is group of disorders forms one of the most important and identi- able causes of chronic kidney disease (CKD) in infants and children.1 Congenital obstructive uropathy constitutes a part of the spectrum of the congenital anomalies of the kidney and urinary tract (CAKUT), which occurs in 1 of 1000 live births and counts for 50% to 56% of CKD and end-stage renal disease (ESRD) in children of all ages.2-4
Because urinary tract obstruction during fetal life has serious consequences for the structural and functional development of kidneys and the urinary tract, there is a clear need for early diagnosis, for appropriate and timely interventions, and to monitor progression and response to therapy. is chapter reviews the causes and pathophysiology of urinary tract obstruction, discusses antenatal and
postnatal clinical manifestations, and examines clinical management.
