ABSTRACT
Pulmonary hypertension (PH) associated with left heart disease is the most common form of pulmonary hypertension encountered in clinical practice today. Although pulmonary hypertension in the context of left heart disease is a marker of worse prognosis and disease severity, it is unknown whether its primary treatment is beneficial, and its pathophysiology remains incompletely understood. An important step to the future study of this important clinical problem will be to standardize definitions across disciplines so as to facilitate an evidence base that is interpretable and applicable to clinical practice. This chapter provides a review and interpretation of the current available literature to understand PH in left heart disease and to frame key questions for future investigation.
