Pulmonary hypertension in sickle cell disease and thalassemia

The hemoglobinopathies are among the most common genetic disorders in the world. An estimated 5% of those in the global population are carriers of variants in either α or β globin genes resulting in 2 major red blood cell disorders, the thalassemia syndromes and sickle cell disease (SCD). These are autosomal recessive conditions that affect over 30 million people worldwide (1,2).