ABSTRACT
The retina is the main light-sensing region of the eye. The presumptive eye field is specified prior to the development of the optic vesicles. The cells are involved in the conversion of the light signal into a chemical signal by the process of phototransduction, which is passed onto the downstream inner retinal neurons. Retinal ganglion cells are one of the first neurons to arrive from the retinal stem cells during mammalian development. These cells are normally generated by the eye in excess and get pruned out as appropriate connectivity develops with the other generated retinal neurons. The induced pluripotent stem cells lines were differentiated to neuroretinal lineage, and rod photoreceptors identified by the infection of the culture with an adenoviral vector-containing neural retina leucine zipper promoter-driven enhanced Rx-green fluorescent protein. There are treatments available for glaucoma, administered via eye drops, which lower the pressure in the eye. These are particularly effective at the early stages of the disease.
