This chapter discusses the basic features of the concept and present several examples of networks related to regional learning in rural parts of Eastern Saxony. The learning region provides a conceptual framework for regional stakeholders to face the challenges of social and economic development which result from the current round of globalisation and Europeanization. PONTES and KRABAT demonstrate how regional learning works on a practical level in Eastern Saxony. The chances and challenges of European and global integration are reflected in both initiatives. PONTES seek a perspective on the development of a trans-border market for education in the Euro region Neie-Nisa-Nysa. Initially fuelled by public funds, the exchange of ideas of actors in the three parts of the Euro region led to co-operative structures. KRABAT evolved around the idea of self-organisation. The Sorbian culture was seen as potential for endogenous development on which to build regional development. Regional actors learned through co-operation and bargaining processes to identify regional potential.