Attention to the feedback-relevant places (FRP) mechanism provides important evidence to the analyst of why a shift in explanation occurs at a particular moment, and what that implies about the cuing and reliability priority of certain knowledge elements. Interaction analysis can directly enhance a core practice of knowledge analysis. The chapter describes a particular mechanism of interaction that speakers and listeners use during explanatory narratives. Sequential organization is a description of the structure of interaction on a moment-by-moment basis and an explanation of this structure in terms of the unwritten rules and expectations of human interaction. As a substantial body of work in sociolinguistics, linguistic anthropology, ethnomethodology, and conversation analysis has demonstrated, human interactions are facilitated and constrained by a multitude of unwritten rules and expectations. At the end of each unit, a moment, called a transition-relevant place (TRP), occurs where speaker change is expected to happen.