This chapter describes how nurse-led clinics have developed in the UK, summarising the key changes to legislation that have enabled nurses to lead services and develop nurse-led clinics. Implications for professional practice will be discussed, including education, training and clinical competence within nurse-led clinics. The different methods of assessing clinical competencies will be outlined, and consideration will be given to the merits of medical mentors, clinical supervision and systems of ongoing clinical appraisals. There will also be a step-by-step plan of how to set up a nurse-led clinic, including general points for consideration and tips for success. The importance of evaluation through audit and research will be discussed, including different methods that may be used.