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Regulatory changes to professional practice together with key changes in legislation have provided the backdrop for developments in nursing practice, including nurse-led clinics. Nurses in the UK have been keen to embrace such developments and expand their current roles, or create new roles within advanced nursing practice. This chapter describes how nurse-led clinics have developed in the UK, and summarises the key changes to legislation that have enabled nurses to lead services and develop nurse-led clinics. Within oncology there has been a rapid increase in the number and range of nurse-led clinics in the UK over the past ten years. The chapter discusses implications for professional practice, including education, training and clinical competence within nurse-led clinics. Few studies report what training nurses complete in order to undertake their extended role within nurse-led clinics. The chapter outlines the different methods of assessing clinical competencies, and discusses the importance of evaluation through audit and research, including different methods that may be used.