ABSTRACT
Nanoemulsion effectively serves as a nanocarrier for the drug delivery as well as delivery of potential bioactive compounds in the management of various diseases. It is a colloidal dispersion with high kinetic stability, low viscosity, and optically transparent system with mean droplet size typically ranging from 10 to 200 nm. It has great potential for encapsulating the active therapeutics in its inner core and improves the stability profile of encapsulated moiety by providing protection against external milieu. Encapsulation of active therapeutics into inner core of nanoemulsions system can offer improvements in the chemical and/or enzymatic stability of active therapeutics as well. Nanoemulsions can be fabricated from generally recognized as safe ingredients as isotropic mixtures and exploiting simple and easy techniques such as vortexing and homogenization. Some of the potential advantages of nanoemulsions over conventional emulsions include significantly higher bioaccessibility and greater stability. This chapter focuses on the formulation insights, applications, and recent advancement in the field of nanoemulsion-based drug delivery systems. In addition, in vivo fate of
nanoemulsion-based drug delivery systems as well as suitability of such carrier system for the delivery of active therapeutics through oral, parenteral, transdermal, ocular, and intranasal routes is also addressed.
