chapter  4
The Strategy of the Picornavirus Genome: Some Implications for Chemotherapy
ByPeter D. Cooper
Pages 18

A great deal of information is now available on the molecular mechanisms of picornavirus replication. Unfortunately, we do not know much about the details of many of the individual steps, particularly the nature and actions of the replicases, and we understand others (such as penetration, regulation, and assembly) rather imperfectly. Nevertheless, the general outline of their overall scheme of gene function and replication (“genome strategy”) can be almost completely discerned at the present time. The concept of strategy can most directly be categorized and described in terms of the total information capacity of the genome, i.e., of the genetic map.