chapter  14
Coupling between Na+/H+ and Cl/HCO3 Exchange in pH and Volume Regulation
ByPeter M. Cala, Sergio Grinstein
Pages 8

In recent years a variety of cell types have been shown to utilize Na+/H+ exchange to regulate cell volume or cytoplasmic pH. The present review will focus upon the biological and physical criteria which determine the extent to which net Na+/H+ exchange flux will alter the cellular volume and/or pH. We will speculate with regard to the control/sensing mechanisms responsible for the regulation of these parameters and their interplay. Initially, however, we will briefly review the criteria for identification of Na+/H+ exchange and the mechanisms that determine its activation and deactivation.