chapter  2
8 Pages

Movement Disorders

WithDennis Allen Jewett

Movement disorders present one of the most challenging problems of diagnosis and treatment in clinical neurology, often manifesting a combination of various motor disorders, the origins of which are incompletely understood and which may result in dysfunction ranging from minor changes in lifestyle to major disability. The unavailability of suitable models in which movement disorders could be reliably produced and which resembled similar disorders in humans limited research in this area until nonhuman primates became the focus of this investigation almost two decades ago. The red nucleus and its connections are important to understanding disorders of movement in man, although isolated lesions in this area are rare. The phenomenon of torticollis is a particularly troublesome problem in clinical neurology, and a suitable model for study may evolve from the type of investigations reported by Crossman and Sambrook.