ABSTRACT
The monoamine oxidase inhibitors (MAOIs) were rescued from premature condemnation by keen detective work in the elucidation of the “cheese reaction” as responsible for reports of serious hypertensive reactions. A number of research groups have demonstrated a clear-cut correlation of degree of monoamine oxidase (MAO) inhibition and therapeutic response to MAOI. Amid all of the controversy surrounding the dangers of MAOI treatment, the most extreme warning has been reserved for combined treatment with tricyclic antide-presants. A wide range of side effects attributed to MAOI can be grouped into several categories. A large number of side effects are similar to the anticholinergic side effects seen with tricyclic antidepressant. Studies of MAOI effectiveness in atypical depression have provided the predominant initial and persisting enthusiasm for the drugs. Use of the laboratory for therapeutic drug monitoring can reduce side effects and improve efficacy.
