ABSTRACT
Radioimmunotherapy (RAIT) application has to overcome many difficulties related to monoclonal antibodies tumor access, to antigen expression in the target, and neoplastic tissue radiosensitivity. While successful results were achieved in lymphoma and other hematologic malignancies, RAIT approach in solid tumors gave rise to favorable outcomes only in a limited number of cases. In most cases RAIT was applied as second or third line therapy. Many efforts are being made to improve RAIT results by applying methods which enhance antibody accretion on the tumor and, its irradiation. Only one patient was immediately submitted to RAIT following operation. As in every other protocol concerning treatment of malignant gliomas, surgery was of great importance in obtaining initial two log cell kill and removal of recurring tumor if a reasonable indication to second or third intervention was seen. So-called "radical surgery" greatly improves the effect of adjuvant therapies since the elimination of necrotic tissue and of neoplastic cells quiescent phase enhances their cytolytic effect.
