ABSTRACT
This chapter discusses the particular ideas concerning the organization of the eukaryotic genome and the regulation of transcription. One of the main ideas in the models of transcripton regulation proposed by R. J. Britten and E. H. Davidson is a concept of the involvement of moderately repeated deoxyribonucleic acid (DNA) sequences in the recognition of regulatory proteins or ribonucleic acid (RNA). In other words, some of these repeats are postulated to be the acceptor sites of transcriptons. The acceptor zone does not carry structural information but contains a number of acceptor sites that are able to interact with the regulatory or structural proteins of chromatin which control the processes of transcription. It is clear that the model is based on two main assumptions: that high molecular weight de-repressor RNA (dRNA) is a physical precursor of RNA, and that messenger RNA (mRNA) is located close to the end of the precursor molecule.
