ABSTRACT
Optical isomers, or enantiomers, are absolutely identical to each other with respect to all their physical and chemical properties, so that the difference in their spatial structures can manifest itself only through their interaction with a chiral structure or field. A two-point attachment of the chiral agent to the enantiomeric structure is, as a matter of principle, insufficient for chiral recognition. In order to achieve a significant discrimination of the enantiomers "single-step" interaction processes with the resolving agents, the enantioselectivity of the latter must be very high. When loaded with copper (II), it provided high enantioselectivity in the separation of a number of racemic dansyl-amino acids, as well as salicylaldehyde Schiff bases of primary amino alcohols including ca-techolamino alcohols. The chapter discusses the influence of the varying parameters of chromatography on the chiral recognition of enantiomers. It outlines development of silica-bonded chiral phases clearly reflects the main trend in modem liquid chromatography which consists of enhancing the efficiency of chromato-graphic systems.
