ABSTRACT
I. Introduction 34
A. Functions of Glycogen in Specific Tissues 34 1. Liver
34 2. Muscle 34 3. Other Tissues 35
B. Enzymes of Glycogen Metabolism — Overview of Recent Developments
35 1. Glycogen Synthase
36 II. Phosphorylase Kinase 36
A. Muscle Phosphorylase Kinase 36
1. Structure 36
2. Activity in Resting Muscle 36
a. Phosphorylase Kinase a 36 b. Phosphorylase Kinase b 37 3. Activity in Contracting Muscle
37 a. Effects of Calmodulin 37 b. Effects of Troponin
38 c. Phosphorylase Kinase Deficiency
38 B. Liver Phosphorylase Kinase
38 III. Glycogen Synthase Kinase
39 A. Classification 39 B. Muscle Glycogen Synthase Kinases 39
I. Hormonal Effects 39
a. Epinephrine 39 b. Insulin 40
C. Liver Glycogen Synthase Kinases 41 D. Other Tissues
41 IV. Phosphoprotein Phosphatase 42
A. Development of Concepts 42 B. Classification of Protein Phosphatases 42
1. Type-I Protein Phosphatase 43 2. Type-2 Protein Phosphatases 43
a. Protein Phosphatase 2A 43 b. Protein Phosphatase 2B 43 c. Protein Phosphatase 2C 44
C. Tissue Distribution of Phosphatases 44 D. Heat-Stable Inhibitors 44
1. Inhibitor-1 44
a. Phosphorylation 44 V. Summary and Conclusions
References 47
glucose concentration by an insulin induced coordinated increase in glucose uptake' and activity of glycogen synthase."
