ABSTRACT
The lipoprotein synthesis takes place both in the liver and intestine. Cholesterol metabolism is an important step in the lipoprotein synthesis, producing one of its main components. The transport of both endogenously synthesized lipids and dietary lipids in the circulation to target organs takes place as lipoprotein complexes. Fatty acids originate from dietary chylomicrons, liver, and adipose tissue. The catabolism of chylomicrons takes place in the peripheral muscle and adipose tissues. The catabolism of very low density lipoproteins is much similar to that of the chylomicrons. Triglyceride serves possibly as a signal to the cellular receptors regulating the cholesterol synthesis while a defect in this receptor may prevent the identification of apolipoprotein triglyceride yielding to the increased intracellular cholesterol accumulation. The lipoprotein lipase enzyme has been found in all species studied and in numerous tissues, such as adipose tissue, muscle, lungs, kidneys, lactating mammary glands, and large blood vessels.
