ABSTRACT
Hyperlipoproteinemias are important genetic or secondary disorders of lipoprotein metabolism which may be a problem prognostically in terms of the development of coronary heart disease. The metabolic disorder is probably the absence of low density lipoprotein (LDL) receptors in the peripheral cells. Type I hyperlipoproteinemia is characterized by the decreased activity of the lipoprotein lipase enzyme which leads to the decreased removal of chylomicron triglycerides. Vitamin E may have many important functions in the body related to its properties as a powerful antioxidant, it does not have any marked additional effects on diet and lipid-lowering drugs in the regulation of plasma lipoproteins. Para-aminosalisylic acid has proved to be an effective drug in lowering serum lipids in types II and IV hyperlipoproteinemias. This drug decreases both total cholesterol and triglyceride levels significantly, fractions involved are very LDL and LDL lipoproteins. The environmental contaminants may influence serum lipoprotein levels.
