ABSTRACT
The fusion of nanotechnology with medicine has offered a plethora of opportunity to control, manipulate, study, and manufacture structures and devices at the nanometer size range for biomedical applications, including drug delivery. Encapsulation of drugs into nanoparticles offers a great opportunity to improve the standard care and prognosis for challenging healthcare issues such as impaired wound healing. In fact, the use of nanoparticulate drug delivery vehicles for wound healing has been predicted to revolutionize the future of diabetic therapy. The slow and sustained release of the encapsulated drug from the nanoparticle can increase the safety of the drug for topical delivery, as the whole amount of the encapsulated drug is never in direct contact with the skin at one time. Controlled-release wound healing formulations are also highly beneficial in management of chronic wounds, as they eliminate the need for frequent dressing changes thus increasing patient compliance. Reduced dose, along with higher localized concentration and prolonged delivery at the wounds, can be achieved avoiding high dose, systemic exposure to the drugs. In addition, susceptible drugs such as growth factors can also be delivered safely while there is also a scope for tailoring their release profiles.
