ABSTRACT
ABSTRACT: Atherosclerosis causes heart disease and stroke and is a main cause of death in many countries. Nanoliposomes are a potential candidate for use in drug targeting for its treatment. The size of the nanoliposomes affects their cellular uptake. An optimal size range is necessary for effective site-specific drug delivery. Such optimum-sized nanoliposomes were developed. Their sizes were characterized in this study using dynamic light scattering and nanoparticle tracking analysis. The sizes of the nanoliposomes were found to be in the ranges of 79-128 nm via the former method and 86-99 nm via the latter. Liposomes grafted with polyethylene glycol show an improved stability and increased circulation time, while those grafted with fluocinolone acetonide help to reduce inflammation. It was observed that normal nanoliposomes had a larger size than these grafted liposomes, which each had a larger size than those grafted with both polyethylene glycol and fluocinolone acetonide.
